Cholesterol modulates Orai1 channel function

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00463164" target="_blank" >RIV/61388971:_____/16:00463164 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1126/scisignal.aad7808" target="_blank" >http://dx.doi.org/10.1126/scisignal.aad7808</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/scisignal.aad7808" target="_blank" >10.1126/scisignal.aad7808</a>

Result language
angličtina
Original language name
Cholesterol modulates Orai1 channel function
Original language description
STIM1 (stromal interaction molecule 1) and Orai proteins are the essential components of Ca2+ release-activated Ca2+ (CRAC) channels. We focused on the role of cholesterol in the regulation of STIM1-mediated Orai1 currents. Chemically induced cholesterol depletion enhanced store-operated Ca2+ entry (SOCE) and Orai1 currents. Furthermore, cholesterol depletion in mucosal-type mast cells augmented endogenous CRAC currents, which were associated with increased degranulation, a process that requires calcium influx. Single point mutations in the Orai1 amino terminus that would be expected to abolish cholesterol binding enhanced SOCE to a similar extent as did cholesterol depletion.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—

Project
<a href="/en/project/GA13-21053S" target="_blank" >GA13-21053S: Investigating the Symmetric Allosteric Mechanism of Hexameric Escherichia coli Arginine Repressor using Computational Simulations</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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