The mechanism of RNA 5 ' capping with NAD(+), NADH and desphospho-CoA
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00463264" target="_blank" >RIV/61388971:_____/16:00463264 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11320/16:10333931
Result on the web
<a href="http://dx.doi.org/10.1038/nature18622" target="_blank" >http://dx.doi.org/10.1038/nature18622</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/nature18622" target="_blank" >10.1038/nature18622</a>
Alternative languages
Result language
angličtina
Original language name
The mechanism of RNA 5 ' capping with NAD(+), NADH and desphospho-CoA
Original language description
The chemical nature of the 5' end of RNA is a key determinant of RNA stability, processing, localization and translation efficiency(1,2), and has been proposed to provide a layer of 'epitranscriptomic' gene regulation(3). Recently it has been shown that some bacterial RNA species carry a 5'-end structure reminiscent of the 5' 7-methylguanylate 'cap' in eukaryotic RNA. In particular, RNA species containing a 5'-end nicotinamide adenine dinucleotide (NAD+) or 3'-desphospho-coenzyme A (dpCoA) have been identified in both Gram-negative and Gram-positive bacteria(3-6). It has been proposed that NAD(+), reduced NAD(+) (NADH) and dpCoA caps are added to RNA after transcription initiation, in a manner analogous to the addition of 7-methylguanylate caps(6-8).
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA15-05228S" target="_blank" >GA15-05228S: Deciphering the Cellular Role of HelD, a Helicase-like Protein Associated with Bacterial RNA Polymerase.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature
ISSN
0028-0836
e-ISSN
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Volume of the periodical
535
Issue of the periodical within the volume
7612
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
444-447
UT code for WoS article
000380344200045
EID of the result in the Scopus database
2-s2.0-84978123660