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Prognostic Significance of TMPRSS2-ERG Fusion Gene in Prostate Cancer

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00464251" target="_blank" >RIV/61388971:_____/16:00464251 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11140/16:10326040 RIV/00669806:_____/16:10326040

  • Result on the web

    <a href="http://dx.doi.org/10.21873/anticanres.11037" target="_blank" >http://dx.doi.org/10.21873/anticanres.11037</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.21873/anticanres.11037" target="_blank" >10.21873/anticanres.11037</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Prognostic Significance of TMPRSS2-ERG Fusion Gene in Prostate Cancer

  • Original language description

    Background/Aim: Current research of prostate cancer (PCa) offers a promising way of identifying patients with adverse prognosis who do benefit from radical treatment that can affect quality of life as resections are associated with numerous side-effects. The aim of our study was to evaluate the relationship of TMPRSS2-ERG fusion gene status, tumor tissue prostate-specific antigen (PSA), prostate cancer antigen 3 (PCA3), miR-23b, miR-26a and miR-221 expression levels in combination with preoperative serum PSA level to the risk of PCa recurrence after radical prostatectomy. Patients and Methods: The study group consisted of 108 patients who underwent radical prostatectomy. PSA was measured in peripheral blood collected preoperativelly. The expression of TMPRSS2-ERG transcript and the expression of miR-23b, miR-26a and miR-221 in formalin-fixed, paraffin-embedded (FFPE) tumor tissues was analyzed by reverse transcription (RT) real-time polymerase chain reaction (PCR).

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Anticancer Research

  • ISSN

    0250-7005

  • e-ISSN

  • Volume of the periodical

    36

  • Issue of the periodical within the volume

    7

  • Country of publishing house

    GR - GREECE

  • Number of pages

    7

  • Pages from-to

    4787-4793

  • UT code for WoS article

    000384001800057

  • EID of the result in the Scopus database

    2-s2.0-84991728589