Comparison of Inflammatory Response to Transgastric and Transcolonic NOTES

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00465577" target="_blank" >RIV/61388971:_____/16:00465577 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/16:00059991
Result on the web
<a href="http://dx.doi.org/10.1155/2016/7320275" target="_blank" >http://dx.doi.org/10.1155/2016/7320275</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2016/7320275" target="_blank" >10.1155/2016/7320275</a>

Result language
angličtina
Original language name
Comparison of Inflammatory Response to Transgastric and Transcolonic NOTES
Original language description
Aims. The aim of our study was to determine the physiologic impact of NOTES and to compare the transgastric and transcolonic approaches. Methods. Thirty pigs were randomized to transgastric, transcolonic, or laparoscopic peritoneoscopy. Blood was drawn and analyzed for C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-(IL-) 1 beta, IL-6, WBCs, and platelets. Results. Endoscopic closure with an OTSC was successful in all 20 animals. The postoperative course was uneventful in all animals. CRP values rose on day 1 in all animals and slowly declined to baseline levels on day 14 with no differences between the groups(p > 0.05, NS). The levels of TNF-alpha. were significantly increased in the transcolonic group (p < 0.01); however this difference was already present prior to the procedure and remained unchanged. No differences were observed in IL1-beta. and IL-6 values. There was a temporary rise of WBC on day 1 and of platelets on day 7 in all groups (p > 0.05, NS). Conclusions. Transgastric, transcolonic, and laparoscopic peritoneoscopy resulted in similar changes in systemic inflammatory markers. Our findings do not support the assumption that NOTES is less invasive than laparoscopy.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Project
<a href="/en/project/NS10525" target="_blank" >NS10525: Transluminal surgical endoscopy ? systemic response and bacterial translocation with respect to site of access to peritoneal cavity</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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