The assembly and function of perinuclear actin cap in migrating cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F17%3A00474654" target="_blank" >RIV/61388971:_____/17:00474654 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s00709-017-1077-0" target="_blank" >http://dx.doi.org/10.1007/s00709-017-1077-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00709-017-1077-0" target="_blank" >10.1007/s00709-017-1077-0</a>

Result language
angličtina
Original language name
The assembly and function of perinuclear actin cap in migrating cells
Original language description
Stress fibers are actin bundles encompassing actin filaments, actin-crosslinking, and actin-associated proteins that represent the major contractile system in the cell. Different types of stress fibers assemble in adherent cells, and they are central to diverse cellular processes including establishment of the cell shape, morphogenesis, cell polarization, and migration. Stress fibers display specific cellular organization and localization, with ventral fibers present at the basal side, and dorsal fibers and transverse actin arcs rising at the cell front from the ventral to the dorsal side and toward the nucleus. Perinuclear actin cap fibers are a specific subtype of stress fibers that rise from the leading edge above the nucleus and terminate at the cell rear forming a dome-like structure. Perinuclear actin cap fibers are fixed at three points: both ends are anchored in focal adhesions, while the central part is physically attached to the nucleus and nuclear lamina through the linker of nucleoskeleton and cytoskeleton (LINC) complex. Here, we discuss recent work that provides new insights into the mechanism of assembly and the function of these actin stress fibers that directly link extracellular matrix and focal adhesions with the nuclear envelope.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology

Project
<a href="/en/project/GA13-06405S" target="_blank" >GA13-06405S: Role of the ERK-RSK signaling module in the temporal control of epithelial-mesenchymal transition.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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