Antibody Repertoire Development in Swine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F17%3A00476120" target="_blank" >RIV/61388971:_____/17:00476120 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1146/annurev-animal-022516-022818" target="_blank" >http://dx.doi.org/10.1146/annurev-animal-022516-022818</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1146/annurev-animal-022516-022818" target="_blank" >10.1146/annurev-animal-022516-022818</a>
Alternative languages
Result language
angličtina
Original language name
Antibody Repertoire Development in Swine
Original language description
This report decribes the domestication of the species, explore its value to agriculture and bioscience, and compare its immunoglobulin (Ig) genes to those of other vertebrates. For encyclopedic information, we cite earlier reviews and chapters. We provide current gene maps for the heavy and light chain loci and describe their polygeny and polymorphy. B-cell and antibody repertoire development is a major focus, and we present findings that challenge several mouse-centric paradigms. We focus special attention on the role of ileal Peyer's patches, the largest secondary lymphoid tissues in newborn piglets and a feature of all artiodactyls. We believe swine fetal development and early class switch evolved to provide natural secretory IgA antibodies able to prevent translocation of bacteria from the gut while the bacterial PAMPs drive development of adaptive immunity. We discuss the value of using the isolator piglet model to address these issues.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Annual Review of Animal Biosciences
ISSN
2165-8102
e-ISSN
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Volume of the periodical
5
Issue of the periodical within the volume
FEB 17
Country of publishing house
US - UNITED STATES
Number of pages
25
Pages from-to
255-279
UT code for WoS article
000396050700013
EID of the result in the Scopus database
2-s2.0-85013480780