Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F17%3A00483350" target="_blank" >RIV/61388971:_____/17:00483350 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1126/scisignal.aao0358" target="_blank" >http://dx.doi.org/10.1126/scisignal.aao0358</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/scisignal.aao0358" target="_blank" >10.1126/scisignal.aao0358</a>

Result language
angličtina
Original language name
Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription
Original language description
The mutation of Orai1 channel resulting in constitutively active gating were investigated. Analysis of the constitutively open Orai1 mutant channels revealed two fundamental gates that enabled Ca2+ influx: Arginine side chains were displaced so they no longer blocked the pore, and a chain of water molecules formed in the hydrophobic pore region. Together, these results enabled us to identify a cluster of Orai1 mutations that trigger Ca2+ permeation associated with gene transcription and provide a gating mechanism for Orai1.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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