ABCE1: A special factor that orchestrates translation at the crossroad between recycling and initiation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F17%3A00483785" target="_blank" >RIV/61388971:_____/17:00483785 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1080/15476286.2016.1269993" target="_blank" >http://dx.doi.org/10.1080/15476286.2016.1269993</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/15476286.2016.1269993" target="_blank" >10.1080/15476286.2016.1269993</a>

Result language
angličtina
Original language name
ABCE1: A special factor that orchestrates translation at the crossroad between recycling and initiation
Original language description
For many years initiation and termination of mRNA translation have been studied separately. However, a direct link between these 2 isolated stages has been suggested by the fact that some initiation factors also control termination and can even promote ribosome recycling, i.e. the last stage where post-terminating 80S ribosomes are split to start a new round of initiation. Notably, it is now firmly established that, among other factors, ribosomal recycling critically requires the NTPase ABCE1. However, several earlier reports have proposed that ABCE1 also somehow participates in the initiation complex assembly. Based on an extended analysis of our recently published late-stage 48S initiation complex from rabbit, here we provide new mechanistic insights into this putative role of ABCE1 in initiation. This point of view represents the first structural evidence in which the regulatory role of the recycling factor ABCE1 in initiation is discussed and establishes a corner stone for elucidating the interplay between ABCE1 and several initiation factors during the transit from ribosomal recycling to formation of the elongation competent 80S initiation complex.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology

Project
<a href="/en/project/GA14-05394S" target="_blank" >GA14-05394S: Structure and function of the human translation initiation factor 3 (eIF3) and its associated eIFs.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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