Potential of the strain Raoultella sp KDF8 for removal of analgesics

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F18%3A00489382" target="_blank" >RIV/61388971:_____/18:00489382 - isvavai.cz</a>
Alternative codes found
RIV/86652036:_____/18:00489382 RIV/00216208:11310/18:10368407
Result on the web
<a href="http://dx.doi.org/10.1007/s12223-017-0563-2" target="_blank" >http://dx.doi.org/10.1007/s12223-017-0563-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s12223-017-0563-2" target="_blank" >10.1007/s12223-017-0563-2</a>

Result language
angličtina
Original language name
Potential of the strain Raoultella sp KDF8 for removal of analgesics
Original language description
The bacterial strain KDF8 capable of growth in the presence of diclofenac and codeine analgesics was obtained after chemical mutagenesis of nature isolates from polluted soils. The strain KDF8 was identified as Raoultella sp. based on its morphology, biochemical properties, and 16S rRNA gene sequence. It was deposited in the Czech Collection of Microorganisms under the number CCM 8678. A growing culture efficiently removed diclofenac (92% removal) and partially also codeine (about 30% degradation) from culture supernatants within 72 h at 28 degrees C. The degradation of six analgesics by the whole cell catalyst was investigated in detail. The maximum degradation of diclofenac (91%) by the catalyst was achieved at pH(INI) of 7 (1 g/L diclofenac). The specific removal rate at high concentrations of diclofenac and codeine increased up to 16.5 mg/g(CDW) per h and 5.1 mg/g(CDW) per h, respectively. HPLC analysis identified 4'-hydroxydiclofenac as a major metabolite of diclofenac transformation and 14-hydroxycodeinone as codeine transformation product. The analgesics ibuprofen and ketoprofen were also removed, albeit to a lower extent of 3.2 and 2.0 mg/g(CDW) per h, respectively. Naproxen and mefenamic acid were not degraded.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology

Project
<a href="/en/project/TH02030337" target="_blank" >TH02030337: Determination of distribution of pharmacologically active compounds and their biological degradation during waste water treatment processes</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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