Dysfunction of HPV16-specific CD8+T cells derived from oropharyngeal tumors is related to the expression of Tim-3 but not PD-1
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F18%3A00497022" target="_blank" >RIV/61388971:_____/18:00497022 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/18:10375431 RIV/00216208:11130/18:10375431 RIV/00216208:11310/18:10375431 RIV/00064203:_____/18:10375431
Result on the web
<a href="http://dx.doi.org/10.1016/j.oraloncology.2018.05.010" target="_blank" >http://dx.doi.org/10.1016/j.oraloncology.2018.05.010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.oraloncology.2018.05.010" target="_blank" >10.1016/j.oraloncology.2018.05.010</a>
Alternative languages
Result language
angličtina
Original language name
Dysfunction of HPV16-specific CD8+T cells derived from oropharyngeal tumors is related to the expression of Tim-3 but not PD-1
Original language description
Background: Human papillomavirus (HPV) type 16 infection is one of the most important etiological agents of oropharyngeal squamous cell carcinoma. Patients with HPV-associated carcinomas of the head and neck were reported to have a better clinical outcome than patients with HPV-negative tumors. Because HPV16 E6 and E7 oncoproteins are highly immunogenic and constitutively expressed, HPV-specific T cell immunity may play the key role in improving the prognosis of these patients. nMethods: Tumor-derived T cells were expanded in high levels of IL-2 and stimulated with HPV16 E6/E7 peptides in the presence or absence of anti-PD-1 monoclonal antibody nivolumab and soluble Tim-3. nResults: HPV16-specific tumor-infiltrating T cells were present in 73.1% of HPV-associated oropharyngeal tumors. HPV16 specific CD8 + TILs were able to produce IFN gamma upon specific stimulation and predominantly expressed PD-1 but not Tim-3. Specific IFN gamma production was further enhanced after a blockade of both PD-1 and Tim-3 pathways but not after a PD-1 blockade alone. Additionally, the specific stimulation of anti-HPV16 CD8 + T cells suppressed Tim-3 upregulation after the PD-1 blockade. nConclusion: Our data provide the rationale for combination cancer immunotherapy approaches, including the dual blockade of PD-1 and Tim-3 and, potentially, the use of HPV16-directed therapeutic vaccines.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Oral Oncology
ISSN
1368-8375
e-ISSN
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Volume of the periodical
82
Issue of the periodical within the volume
JUL
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
75-82
UT code for WoS article
000436776400012
EID of the result in the Scopus database
2-s2.0-85047095675