Human gut microbiota transferred to germ-free NOD mice modulate the progression towards type 1 diabetes regardless of the pace of beta cell function loss in the donor

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F19%3A00510175" target="_blank" >RIV/61388971:_____/19:00510175 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/19:10394981 RIV/00064203:_____/19:10394981

Result on the web

<a href="https://link.springer.com/article/10.1007%2Fs00125-019-4869-2" target="_blank" >https://link.springer.com/article/10.1007%2Fs00125-019-4869-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00125-019-4869-2" target="_blank" >10.1007/s00125-019-4869-2</a>

Result language

angličtina

Original language name

Human gut microbiota transferred to germ-free NOD mice modulate the progression towards type 1 diabetes regardless of the pace of beta cell function loss in the donor

Original language description

Aims/hypothesis This study aimed to assess the ability of human gut microbiota to delay the onset of type 1 diabetes when transferred into germ-free NOD mice.nMethods Two children with rapid and three children with slow beta cell function loss (as assessed by C-peptide AUC change in the mixed-meal tolerance tests performed 1 and 12 months after type 1 diabetes onset), participating in an ongoing trial with gluten-free diet, donated faeces, which were transferred into germ-free NOD mice. The mice were subsequently followed for diabetes incidence.nResults The bacterial profiles of bacteriome-humanised mice had significantly (p < 10(-5)) lower alpha diversity than the donor material, with marked shifts in ratios between the main phyla. Diabetes onset was significantly delayed in all bacteriome-humanised colonies vs germ-free NOD mice, but the pace of beta cell loss was not transferable to the mouse model.nConclusions/interpretation Germ-free NOD mice colonised with human gut microbiome are able to adopt a large proportion of transferred bacterial content, although the ratios of main phyla are reproduced only suboptimally. The recipient mice did not replicate the phenotype of the stool donor in relation to the pace towards type 1 diabetes.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10606 - Microbiology

Project

<a href="/en/project/NV16-27994A" target="_blank" >NV16-27994A: The effect of gluten-free diet on residual beta cell capacity, immune functions and gut microbiome in children with newly diagnosed type 1 diabetes</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Diabetologia

ISSN

0012-186X

e-ISSN

—

Volume of the periodical

62

Issue of the periodical within the volume

7

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

1291-1296

UT code for WoS article

000471176200019

EID of the result in the Scopus database

2-s2.0-85065042286