Lysyl oxidases: linking structures and immunity in the tumor microenvironment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00524076" target="_blank" >RIV/61388971:_____/20:00524076 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/20:10472520
Result on the web
<a href="https://link.springer.com/article/10.1007/s00262-019-02404-x" target="_blank" >https://link.springer.com/article/10.1007/s00262-019-02404-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00262-019-02404-x" target="_blank" >10.1007/s00262-019-02404-x</a>
Alternative languages
Result language
angličtina
Original language name
Lysyl oxidases: linking structures and immunity in the tumor microenvironment
Original language description
The lysyl oxidases (LOXs) are a family of enzymes deputed to cross-link collagen and elastin, shaping the structure and strength of the extracellular matrix (ECM). However, many novel 'non-canonical' functions, alternative substrates, and regulatory mechanisms have been described and are being continuously elucidated. The activity of LOXs, therefore, appears to be integrated into a complex network of signals regulating many cell functions, including survival/proliferation/differentiation. Among these signaling pathways, TGF-β and PI3K/Akt/mTOR, in particular, cross-talk extensively with each other and with LOXs also initiating complex feedback loops which modulate the activity of LOXs and direct the remodeling of the ECM. A growing body of evidence indicates that LOXs are not only important in the homeostasis of the normal structure of the ECM, but are also implicated in the establishment and maturation of the tumor microenvironment. LOXs' association with advanced and metastatic cancer is well established, however, there is enough evidence to support a significant role of LOXs in the transformation of normal epithelial cells, in the accelerated tumor development and the induction of invasion of the premalignant epithelium. A better understanding of LOXs and their interactions with the different elements of the tumor immune microenvironment will prove invaluable in the design of novel anti-tumor strategies.
Czech name
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Czech description
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Classification
Type
J<sub>ost</sub> - Miscellaneous article in a specialist periodical
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Immunology and Immunotherapy
ISSN
0340-7004
e-ISSN
—
Volume of the periodical
69
Issue of the periodical within the volume
2
Country of publishing house
DE - GERMANY
Number of pages
13
Pages from-to
223-235
UT code for WoS article
000492365000001
EID of the result in the Scopus database
2-s2.0-85074338128