Gluten-free diet in children with recent-onset type 1 diabetes: A 12-month intervention trial

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00531995" target="_blank" >RIV/61388971:_____/20:00531995 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/20:43919637 RIV/00216208:11130/20:10404498 RIV/00216208:11320/20:10404498 RIV/00064173:_____/20:N0000068 RIV/00064203:_____/20:10404498

Result on the web

<a href="https://dom-pubs.onlinelibrary.wiley.com/doi/abs/10.1111/dom.13974" target="_blank" >https://dom-pubs.onlinelibrary.wiley.com/doi/abs/10.1111/dom.13974</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/dom.13974" target="_blank" >10.1111/dom.13974</a>

Result language

angličtina

Original language name

Gluten-free diet in children with recent-onset type 1 diabetes: A 12-month intervention trial

Original language description

To test whether a gluten-free diet (GFD) is associated with the deceleration of the decline in beta-cell capacity in non-coeliac children with recently diagnosed type 1 diabetes.nForty-five children (aged 10.2 +/- 3.3 years) were recruited into a self-selected intervention trial: 26 started with a GFD within a median of 38 days postonset, whereas 19 remained on a standard diet. The main outcomes were the decline in C-peptide area under the curve (AUC) in mixed-meal tolerance tests (MMTTs) at 6 and 12 months relative to 1 month after diabetes onset and the difference in insulin dose, insulin dose-adjusted A1c (IDAA1c) and HbA1c assessed every 3 months. The adherence to the GFD was verified by immunoreactive gluten in the stool and by food questionnaires at every visit. Questionnaires were administered to the participants at the end of the intervention at 12 months. The data were analysed as per protocol by linear and longitudinal regression models adjusted for sex, age and baseline variables.nAt 12 months, the difference in C-peptide AUC between subjects in the GFD group and controls was 205 pmol/L (95% CI -223 to 633, P = 0.34) in a model adjusted for age, sex and body weight, and for baseline insulin dose, MMTT C-peptide AUC and HbA1c assessed at 1 month after diagnosis. In a longitudinal analysis of all three time points adjusted for age, sex and body weight, C-peptide declined more slowly in the GFD group than in controls, with the difference in trends being 409 pmol/L/year (P = 0.04). The GFD group had a marginally lower insulin dose (by 0.15 U/kg/day, P = 0.07), a lower IDAA1c (by 1.37, P = 0.01) and a lower mean HbA1c (by 0.7% [7.8 mmol/mol], P = 0.02) than those of the controls at 12 months. There was no appreciable difference between the groups in daily carbohydrate intake (P = 0.49) or in the QoL reported by the patients (P = 0.70) and their parents/caregivers (P = 0.59).nn

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10606 - Microbiology

Project

<a href="/en/project/NV16-27994A" target="_blank" >NV16-27994A: The effect of gluten-free diet on residual beta cell capacity, immune functions and gut microbiome in children with newly diagnosed type 1 diabetes</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Diabetes Obesity & Metabolism

ISSN

1462-8902

e-ISSN

—

Volume of the periodical

22

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

866-872

UT code for WoS article

000522664600017

EID of the result in the Scopus database

2-s2.0-85079159686