BordetellaType III Secretion Injectosome and Effector Proteins
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00535324" target="_blank" >RIV/61388971:_____/20:00535324 - isvavai.cz</a>
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fcimb.2020.00466/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fcimb.2020.00466/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcimb.2020.00466" target="_blank" >10.3389/fcimb.2020.00466</a>
Alternative languages
Result language
angličtina
Original language name
BordetellaType III Secretion Injectosome and Effector Proteins
Original language description
Pertussis, also known as whooping cough, is a resurging acute respiratory disease of humans primarily caused by the Gram-negative coccobacilliBordetella pertussis, and less commonly by the human-adapted lineage ofB. parapertussis(HU). The ovine-adapted lineage ofB. parapertussis(OV)infects only sheep, whileB. bronchisepticacauses chronic and often asymptomatic respiratory infections in a broad range of mammals but rarely in humans. A largely overlapping set of virulence factors inflicts the pathogenicity of these bordetellae. Their genomes also harbor a pathogenicity island, namedbsclocus, that encodes components of the type III secretion injectosome, and adjacentbtrlocus with the type III regulatory proteins. The Bsc injectosome of bordetellae translocates the cytotoxic BteA effector protein, also referred to as BopC, into the cells of the mammalian hosts. While the role of type III secretion activity in the persistent colonization of the lower respiratory tract byB. bronchisepticais well recognized, the functionality of the type III secretion injectosome inB. pertussiswas overlooked for many years due to the adaptation of laboratory-passagedB. pertussisstrains. This review highlights the current knowledge of the type III secretion system in the so-called classicalBordetellaspecies, comprisingB. pertussis, B. parapertussis, andB. bronchiseptica, and discusses its functional divergence. Comparison with other well-studied bacterial injectosomes, regulation of the type III secretion on the transcriptional and post-transcriptional level, and activities of BteA effector protein and BopN protein, homologous to the type III secretion gatekeepers, are addressed.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Cellular and Infection Microbiology
ISSN
2235-2988
e-ISSN
—
Volume of the periodical
10
Issue of the periodical within the volume
SEP 4
Country of publishing house
CH - SWITZERLAND
Number of pages
17
Pages from-to
466
UT code for WoS article
000572210300001
EID of the result in the Scopus database
2-s2.0-85091247186