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Protective Activities of Mucosal Antibodies

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00535967" target="_blank" >RIV/61388971:_____/20:00535967 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/B978-0-12-811924-2.00004-3" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-811924-2.00004-3</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/B978-0-12-811924-2.00004-3" target="_blank" >10.1016/B978-0-12-811924-2.00004-3</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Protective Activities of Mucosal Antibodies

  • Original language description

    Extensive studies of mucosal antibodies actively induced by immunization and infection or passively administered to nonimmunized subjects have convincingly demonstrated the essential role of antibodies in the prevention of mucosally acquired infections. Mucosal antibodies display their protective functions by several mechanisms, depending on their levels and antigen specificity in various external secretions, Ig isotype association, which differs in the intestinal versus genitourinary tract, molecular form, such as monomeric and polymeric Ig, and highly variable glycosylation patterns. The inhibition of antigen uptake, antibody and glycan-mediated interference with microbial attachment to epithelial cell receptors, intraluminal aggregation of bacteria, and the ability to neutralize biologically active antigens such as viruses and bacterial products represent the major protective mechanism of mucosal antibodies. The ability to induce antibodies of desired specificity and relevant effector functions in diverse external secretions, with a focus on the dominant secretory IgA isotype with its advantageous protective potential, is the most important goal in the generation of mucosal vaccines.

  • Czech name

  • Czech description

Classification

  • Type

    C - Chapter in a specialist book

  • CEP classification

  • OECD FORD branch

    30102 - Immunology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Book/collection name

    Mucosal Vaccines

  • ISBN

    978-0-12-811924-2

  • Number of pages of the result

    14

  • Pages from-to

    71-84

  • Number of pages of the book

    881

  • Publisher name

    Academic Press Ltd- Elsevier Science Ltd

  • Place of publication

    Londýn

  • UT code for WoS chapter

    000538933600005