Protective Activities of Mucosal Antibodies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00535967" target="_blank" >RIV/61388971:_____/20:00535967 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/B978-0-12-811924-2.00004-3" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-811924-2.00004-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-811924-2.00004-3" target="_blank" >10.1016/B978-0-12-811924-2.00004-3</a>
Alternative languages
Result language
angličtina
Original language name
Protective Activities of Mucosal Antibodies
Original language description
Extensive studies of mucosal antibodies actively induced by immunization and infection or passively administered to nonimmunized subjects have convincingly demonstrated the essential role of antibodies in the prevention of mucosally acquired infections. Mucosal antibodies display their protective functions by several mechanisms, depending on their levels and antigen specificity in various external secretions, Ig isotype association, which differs in the intestinal versus genitourinary tract, molecular form, such as monomeric and polymeric Ig, and highly variable glycosylation patterns. The inhibition of antigen uptake, antibody and glycan-mediated interference with microbial attachment to epithelial cell receptors, intraluminal aggregation of bacteria, and the ability to neutralize biologically active antigens such as viruses and bacterial products represent the major protective mechanism of mucosal antibodies. The ability to induce antibodies of desired specificity and relevant effector functions in diverse external secretions, with a focus on the dominant secretory IgA isotype with its advantageous protective potential, is the most important goal in the generation of mucosal vaccines.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Mucosal Vaccines
ISBN
978-0-12-811924-2
Number of pages of the result
14
Pages from-to
71-84
Number of pages of the book
881
Publisher name
Academic Press Ltd- Elsevier Science Ltd
Place of publication
Londýn
UT code for WoS chapter
000538933600005