Anorexia nervosa: Gut microbiota-immune-brain interactions

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00539796" target="_blank" >RIV/61388971:_____/20:00539796 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/20:10409334 RIV/00064165:_____/20:10409334

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0261561419301372" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0261561419301372</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clnu.2019.03.023" target="_blank" >10.1016/j.clnu.2019.03.023</a>

Result language

angličtina

Original language name

Anorexia nervosa: Gut microbiota-immune-brain interactions

Original language description

Anorexia nervosa is a psychiatric disorder defined by an extremely low body weight, a devastating fear of weight gain, and body image disturbance, however the etiopathogenesis remains unclear. The objective of the article is to provide a comprehensive review on the potential role of gut microbiota in pathogenesis of anorexia nervosa. Recent advances in sequencing techniques used for microbial detection revealed that this disease is associated with disruption of the composition of normal gut microbiota (dysbiosis), manifested by low microbial diversity and taxonomic differences as compared to healthy individuals. Microorganisms present in the gut represent a part of the so called ´microbiota-gut-brain´axis that affect the central nervous system and thus human behavior via the production of various neuroactive compounds. In addition, cells of the immune system are equipped with receptors for these neuroactive substances. Microbiota of the intestinal system also represent a very important antigenic source. These antigens can mimic some host neuropeptides and neurohormones and thus trigger the production of autoantibodies which cross-react with these compounds. The levels and affinities of these antibodies are thought to be associated with neuropsychiatric conditions including anxiety, depression, and eating and sleep disorders. The study of microbiota function in diseases could bring new insights to the pathogenetic mechanisms.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10606 - Microbiology

Project

<a href="/en/project/NV17-28905A" target="_blank" >NV17-28905A: The Role of Gut Microbiome and Autoimmune Mechanisms in Patients with Anorexia Nervosa</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Nutrition

ISSN

0261-5614

e-ISSN

—

Volume of the periodical

39

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

676-684

UT code for WoS article

000521509800006

EID of the result in the Scopus database

2-s2.0-85063681392