Immune activation by microbiome shapes the colon mucosa: Comparison between healthy rat mucosa under conventional and germ-free conditions

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F21%3A00542580" target="_blank" >RIV/61388971:_____/21:00542580 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/21:00542580 RIV/68378050:_____/21:00542580 RIV/00216208:11310/21:10440285

Result on the web

<a href="https://www.tandfonline.com/doi/full/10.1080/1547691X.2021.1887412" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/1547691X.2021.1887412</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/1547691X.2021.1887412" target="_blank" >10.1080/1547691X.2021.1887412</a>

Result language

angličtina

Original language name

Immune activation by microbiome shapes the colon mucosa: Comparison between healthy rat mucosa under conventional and germ-free conditions

Original language description

Germ-free animals (GF) are those without a microbiome since birth. This particular biological model has become one of special interest with the growing evidence of importance of the microbiome in the life, development, adaptation, and immunity of humans and animals in the environments in which they live. Anatomical differences observed in GF compared with conventionally-reared animals (CV) has given rise to the question of the influence of commensal microflora on the development of structure and function (even immunological) of the bowel. Only recently, thanks to achievements in microscopy and associated methods, structural differences can be better evaluated and put in perspective with the immunological characteristics of GF vs. CV animals. This study, using a GF rat model, describes for the first time the possible influence that the presence of commensal microflora, continuously stimulating mucosal immunity, has on the collagen scaffold organization of the colon mucosa. Significant differences were found between CV and GF mucosa structure with higher complexity in the CV rats associated to a more activated immune environment. The immunological data suggest that, in response to the presence of a microbiome, an effective homeostatic regulation in developed by the CV rats in healthy conditions to avoid inflammation and maintain cytokine levels near the spontaneous production found in the GF animals. The results indicated that collagen scaffold adapted to the immune microenvironment, therefore, it is apparent that the microbiome was able to condition the structure of the colon mucosa.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10606 - Microbiology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

—

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Immunotoxicology

ISSN

1547-691X

e-ISSN

1547-6901

Volume of the periodical

18

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

37-49

UT code for WoS article

000631284200001

EID of the result in the Scopus database

2-s2.0-85103054160