Mitochondrial Retrograde Signaling Contributes to Metabolic Differentiation in Yeast Colonies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F21%3A00545739" target="_blank" >RIV/61388971:_____/21:00545739 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/21:10429196
Result on the web
<a href="https://www.mdpi.com/1422-0067/22/11/5597/htm" target="_blank" >https://www.mdpi.com/1422-0067/22/11/5597/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms22115597" target="_blank" >10.3390/ijms22115597</a>
Alternative languages
Result language
angličtina
Original language name
Mitochondrial Retrograde Signaling Contributes to Metabolic Differentiation in Yeast Colonies
Original language description
During development of yeast colonies, various cell subpopulations form, which differ in their properties and specifically localize within the structure. Three branches of mitochondrial retrograde (RTG) signaling play a role in colony development and differentiation, each of them activating the production of specific markers in different cell types. Here, aiming to identify proteins and processes controlled by the RTG pathway, we analyzed proteomes of individual cell subpopulations from colonies of strains, mutated in genes of the RTG pathway. Resulting data, along with microscopic analyses revealed that the RTG pathway predominantly regulates processes in U cells, long-lived cells with unique properties, which are localized in upper colony regions. Rtg proteins therein activate processes leading to amino acid biosynthesis, including transport of metabolic intermediates between compartments, but also repress expression of mitochondrial ribosome components, thus possibly contributing to reduced mitochondrial translation in U cells. The results reveal the RTG pathway's role in activating metabolic processes, important in U cell adaptation to altered nutritional conditions. They also point to the important role of Rtg regulators in repressing mitochondrial activity in U cells.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/GA19-09381S" target="_blank" >GA19-09381S: Role of mitochondria in yeast colony differentiation and cell viability</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
1422-0067
Volume of the periodical
22
Issue of the periodical within the volume
11
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
5597
UT code for WoS article
000660155800001
EID of the result in the Scopus database
2-s2.0-85106440628