Comparative Aspects of Immunoglobulin Gene Rearrangement Arrays in Different Species

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F22%3A00553320" target="_blank" >RIV/61388971:_____/22:00553320 - isvavai.cz</a>

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fimmu.2022.823145/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fimmu.2022.823145/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fimmu.2022.823145" target="_blank" >10.3389/fimmu.2022.823145</a>

Result language

angličtina

Original language name

Comparative Aspects of Immunoglobulin Gene Rearrangement Arrays in Different Species

Original language description

Studies in humans and mice indicate the critical role of the surrogate light chain in thenselection of the productive immunoglobulin repertoire during B cell development.nHowever, subsequent studies using mutant mice have also demonstrated thatnalternative pathways are allowed. Our recent investigation has shown that somenspecies, such as pig, physiologically use preferential rearrangement of authentic lightnchains, and become independent of surrogate light chains. Here we summarize thenfindings from swine and compare them with results in other species. In both groups, allelicnand isotypic exclusions remain intact, so the different processes do not alter the paradigmnof B-cell monospecificity. Both groups also retained some other essential processes, suchnas segregated and sequential rearrangement of heavy and light chain loci, preferentialnrearrangement of light chain kappa before lambda, and functional k-deleting elementnrecombination. On the other hand, the respective order of heavy and light chainsnrearrangement may vary, and rearrangement of the light chain kappa and lambda onndifferent chromosomes may occur independently. Studies have also confirmed that thensurrogate light chain is not required for the selection of the productive repertoire of heavynchains and can be substituted by authentic light chains. These findings are important fornunderstanding evolutional approaches, redundancy and efficiency of B-cell generation,ndependencies on other regulatory factors, and strategies for constructing therapeuticnantibodies in unrelated species. The results may also be important for explainingninterspecies differences in the proportional use of light chains and for the understandingnof divergences in rearrangement processes. Therefore, the division into two groups maynnot be definitive and there may be more groups of intermediate species.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30102 - Immunology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Immunology

ISSN

1664-3224

e-ISSN

1664-3224

Volume of the periodical

13

Issue of the periodical within the volume

February 2022

Country of publishing house

CH - SWITZERLAND

Number of pages

11

Pages from-to

823145

UT code for WoS article

000761446800001

EID of the result in the Scopus database

2-s2.0-85125246124