Evaluation of estrogenic and antiestrogenic activity in sludge and explanation of individual compound contributions

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F22%3A00557651" target="_blank" >RIV/61388971:_____/22:00557651 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/22:10432572
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0304389421020768?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0304389421020768?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jhazmat.2021.127108" target="_blank" >10.1016/j.jhazmat.2021.127108</a>

Result language
angličtina
Original language name
Evaluation of estrogenic and antiestrogenic activity in sludge and explanation of individual compound contributions
Original language description
Mixture toxicity, including agonistic and antagonistic effects, is an unrevealed environmental problem. Estrogenic endocrine disruptors are known to cause adverse effects for aquatic biota, but causative chemicals and their contributions to the total activity in sewage sludge remain unknown. Therefore, advanced analytical methods, a yeast bioassay and mixture toxicity models were concurrently applied for the characterization of 8 selected sludges with delectable estrogenic activity (and 3 sludges with no activity as blanks) out of 25 samples from wastewater treatment plants (WWTPs). The first applied full logistic model adequately explained total activity by considering the concentrations of the monitored compounds. The results showed that the activity was primarily caused by natural estrogens in municipal WWTP sludge. Nevertheless, activity in a sample originating from a car wash facility was dominantly caused by partial agonists nonylphenols and only a model enabling prediction of all dose-response curve parameters of the final mixture curve explained these results. Antiestrogenic effects were negligible, and effect-directed analysis identified the causative chemicals.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10511 - Environmental sciences (social aspects to be 5.7)

Project
<a href="/en/project/SS02030008" target="_blank" >SS02030008: Centre of environmental research: Waste management, circular economy and environmetal secutiry</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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