Modeling the catarrhal stage of Bordetella pertussis upper respiratory tract infections in mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F22%3A00558663" target="_blank" >RIV/61388971:_____/22:00558663 - isvavai.cz</a>
Result on the web
<a href="https://journals.biologists.com/dmm/article/15/5/dmm049266/275265/Modeling-the-catarrhal-stage-of-Bordetella" target="_blank" >https://journals.biologists.com/dmm/article/15/5/dmm049266/275265/Modeling-the-catarrhal-stage-of-Bordetella</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1242/dmm.049266" target="_blank" >10.1242/dmm.049266</a>

Result language
angličtina
Original language name
Modeling the catarrhal stage of Bordetella pertussis upper respiratory tract infections in mice
Original language description
Pertussis (whooping cough) is a highly transmissible human respiratory disease caused by Bordetella pertussis, a human-restricted pathogen. Animal models generally involve pneumonic infections induced by depositing large numbers of bacteria in the lungs of mice. These models have informed us about the molecular pathogenesis of pertussis and guided development of vaccines that successfully protect against severe disease. However, they bypass the catarrhal stage of the disease, when bacteria first colonize and initially grow in the upper respiratory tract. This is a critical and highly transmissible stage of the infection that current vaccines do not prevent. Here, we demonstrate a model system in which B. pertussis robustly and persistently infects the nasopharynx of TLR4-deficient mice, inducing localized inflammation, neutrophil recruitment and mucus production as well as persistent shedding and occasional transmission to cage mates. This novel experimental system will allow the study of the contributions of bacterial factors to colonization of and shedding from the nasopharynx, as occurs during the catarrhal stage of pertussis, and interventions that might better control the ongoing circulation of pertussis.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10606 - Microbiology

Project
<a href="/en/project/GX19-27630X" target="_blank" >GX19-27630X: Concerted toxin action in Bordetella pertussis virulence</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)