Deciphering the early innate immune response to bordetella pertussis infection

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F23%3A00581908" target="_blank" >RIV/68378050:_____/23:00581908 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/23:00581908
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Deciphering the early innate immune response to bordetella pertussis infection
Original language description
Bordetella pertussis, a strictly human pathogen, elicits a highly contagious respiratory disease known as pertussis, or whooping cough. Current mouse models enabled identification of many bacterial virulence factors and development of pertussis vaccines, but mechanisms underlying the process of B. pertussis transmission during the catarrhal phase of pertussis disease remain largely unexplored due to lack of a convenient animal model. Recently, we have used immunodeficient MyD88 knock-out mice to achieve a human-like high level of nasal mucosa infection that triggers rhinitis and catarrhal shedding of bacteria from mouse nasal cavity, yielding transmission of the infection onto co-housed adult animals.
Czech name
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Czech description
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Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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