In vitro interactions of TiO2 Nanoparticles with earthworm coelomocytes: immunotoxicity assessment. Nanomaterials

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F22%3A00559249" target="_blank" >RIV/61388971:_____/22:00559249 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/22:00572819
Result on the web
<a href="https://www.mdpi.com/books/pdfdownload/book/5502" target="_blank" >https://www.mdpi.com/books/pdfdownload/book/5502</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
In vitro interactions of TiO2 Nanoparticles with earthworm coelomocytes: immunotoxicity assessment. Nanomaterials
Original language description
Titanium dioxide nanoparticles (TiO2 NPs) are manufactured worldwide. Once they arrive in the soil environment, they can endanger living organisms. Hence, monitoring and assessing the effects of these nanoparticles is required. We focus on the Eisenia andrei earthworm immune cells exposed to sublethal concentrations of TiO2 NPs (1, 10, and 100 μg/mL) for 2, 6, and 24 h. TiO2 NPs at all concentrations did not affect cell viability. Further, TiO2 NPs did not cause changes in reactivenoxygen species (ROS) production, malondialdehyde (MDA) production, and phagocytic activity. Similarly, they did not elicit DNA damage. Overall, we did not detect any toxic effects of TiO2 NPs at the cellular level. At the gene expression level, slight changes were detected. Metallothionein, fetidin/lysenin, lumbricin and MEK kinase I were upregulated in coelomocytes after exposure to 10 μg/mL TiO2 NPs for 6 h. Antioxidant enzyme expression was similar in exposed and control cells. TiO2 NPs were detected on coelomocyte membranes. However, our results do not show any strong effects of these nanoparticles on coelomocytes at both the cellular and molecular levels.
Czech name
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Czech description
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Project
<a href="/en/project/QK1910095" target="_blank" >QK1910095: Use of Vermicomposting to Eliminate Micropollutants for Safe Application of Sewage Sludge on Agricultural Land</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name
An Evolutionary and Environmental Perspective of the Interaction of Nanomaterials with the Immune System-The Outcomes of the EU Project PANDORA
ISBN
978-3-0365-3948-5
Number of pages of the result
16
Pages from-to
49-65
Number of pages of the book
220
Publisher name
MDPI
Place of publication
Basel
UT code for WoS chapter
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