Combined microwave dielectrometry and molecular dynamic study of aqueous solutions of human serum albumin with additives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F22%3A00565056" target="_blank" >RIV/61388971:_____/22:00565056 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/22:43905127
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0167732222015197?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0167732222015197?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.molliq.2022.119981" target="_blank" >10.1016/j.molliq.2022.119981</a>

Result language
angličtina
Original language name
Combined microwave dielectrometry and molecular dynamic study of aqueous solutions of human serum albumin with additives
Original language description
We combined the microwave dielectrometry method for the complex permittivity experimental study of aqueous Human Serum Albumin (HSA) solutions and a molecular dynamics simulation of similar mod-elling aqueous solutions. Using microwave dielectrometry we obtained that the real and imaginary parts of complex permittivity of all studied solutions (HSA water solutions, HSA water solutions with NaCl or glucose) decrease at the HSA concentration growing. The molecular dynamics simulation of HSA aqueous solutions showed that the increase of the HSA concentration causes the number of H-bound increase between water and protein molecules and leads to complex permittivity value decrease for the tested solutions. Thus, the molecular dynamics simulation results are in good agreement with microwave dielectrometry experimental data for HSA aqueous solutions with the addition of NaCl and glucose. Our study can be applied in the ecological investigations of wastewater samples owing to demonstrated sensitivity of complex permittivity parameters measured to the small changes of the concentration in the solutions.(c) 2022 Elsevier B.V. All rights reserved.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10610 - Biophysics

Project
<a href="/en/project/GA21-15936S" target="_blank" >GA21-15936S: Effects of Macromolecular Crowding on Enzyme Structure and Kinetics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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