Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F22%3A00565986" target="_blank" >RIV/61388971:_____/22:00565986 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/22:00565986 RIV/00216208:11110/22:10455224 RIV/00216208:11310/22:10455224
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fimmu.2022.1009198/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fimmu.2022.1009198/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fimmu.2022.1009198" target="_blank" >10.3389/fimmu.2022.1009198</a>

Result language
angličtina
Original language name
Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections
Original language description
Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, the relative differences in self-reactivity among individual T-cell clones were appreciated as important factors regulating their fate and immune response, but the role of self-reactivity in T-cell biology is incompletely understood. We addressed the role of self-reactivity in T-cell diversity by generating an atlas of mouse peripheral CD8(+) T cells, which revealed two unconventional populations of antigen-inexperienced T cells. In the next step, we examined the steady-state phenotype of monoclonal T cells with various levels of self-reactivity. Highly self-reactive clones preferentially differentiate into antigen-inexperienced memory-like cells, but do not form a population expressing type I interferon-induced genes, showing that these two subsets have unrelated origins. The functional comparison of naive monoclonal CD8(+) T cells specific to the identical model antigen did not show any correlation between the level of self-reactivity and the magnitude of the immune response.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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