Narcissistic T cells: reactivity to self makes a difference
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F21%3A00531950" target="_blank" >RIV/68378050:_____/21:00531950 - isvavai.cz</a>
Result on the web
<a href="https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15498" target="_blank" >https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15498</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/febs.15498" target="_blank" >10.1111/febs.15498</a>
Alternative languages
Result language
angličtina
Original language name
Narcissistic T cells: reactivity to self makes a difference
Original language description
It has been appreciated for more than three decades that the interactions between the T-cell antigen receptor and self-antigens are the major determinants of the cell fates of developing thymocytes and the establishment of central tolerance. However, recent evidence shows that the level of self-reactivity substantially contributes to fate choices of positively selected mature T cells in homeostasis, as well as during immune responses. This implies that individual clones of peripheral T cells are predisposed to specific functional properties based on the self-reactivity of their antigen receptors. Overall, the relative difference in the self-reactivity among peripheral T cells is an important factor contributing to the diversity of T-cell responses to foreign antigens.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
<a href="/en/project/GJ19-03435Y" target="_blank" >GJ19-03435Y: Naïve, memory, and virtual memory T cells in adaptive immune responses</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
FEBS Journal
ISSN
1742-464X
e-ISSN
1742-4658
Volume of the periodical
288
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
1778-1788
UT code for WoS article
000557716300001
EID of the result in the Scopus database
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