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Narcissistic T cells: reactivity to self makes a difference

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F21%3A00531950" target="_blank" >RIV/68378050:_____/21:00531950 - isvavai.cz</a>

  • Result on the web

    <a href="https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15498" target="_blank" >https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15498</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/febs.15498" target="_blank" >10.1111/febs.15498</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Narcissistic T cells: reactivity to self makes a difference

  • Original language description

    It has been appreciated for more than three decades that the interactions between the T-cell antigen receptor and self-antigens are the major determinants of the cell fates of developing thymocytes and the establishment of central tolerance. However, recent evidence shows that the level of self-reactivity substantially contributes to fate choices of positively selected mature T cells in homeostasis, as well as during immune responses. This implies that individual clones of peripheral T cells are predisposed to specific functional properties based on the self-reactivity of their antigen receptors. Overall, the relative difference in the self-reactivity among peripheral T cells is an important factor contributing to the diversity of T-cell responses to foreign antigens.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30102 - Immunology

Result continuities

  • Project

    <a href="/en/project/GJ19-03435Y" target="_blank" >GJ19-03435Y: Naïve, memory, and virtual memory T cells in adaptive immune responses</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    FEBS Journal

  • ISSN

    1742-464X

  • e-ISSN

    1742-4658

  • Volume of the periodical

    288

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    1778-1788

  • UT code for WoS article

    000557716300001

  • EID of the result in the Scopus database