Detailed insight into chromium species released from failed CoCrMo implants: Ex vivo periprosthetic tissues study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F23%3A00565980" target="_blank" >RIV/61388971:_____/23:00565980 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/23:73621456 RIV/61989592:15310/23:73621456 RIV/00098892:_____/23:10158166

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.35149" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.35149</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jbm.b.35149" target="_blank" >10.1002/jbm.b.35149</a>

Result language

angličtina

Original language name

Detailed insight into chromium species released from failed CoCrMo implants: Ex vivo periprosthetic tissues study

Original language description

This unique study provides information on Cr species and their distribution in periprosthetic tissues of patients with metal-on-polyethylene joint implants. Co-Cr-Mo alloy has been widely used in joint replacement and represents a source of metal derived species. In the case of chromium, previous studies on periprosthetic tissues revealed mainly Cr(III) distribution, whereas the potential release of carcinogenic Cr(VI) species has been still a subject of debate. Here, an analytical approach utilizing speciation and fractionation was developed to analyze periprosthetic tissue samples collected from wide range of patients with failed total hip or knee replacements. The results reveal that Cr(III) is mainly released in the form of insoluble CrPO4 and Cr2O3 particles. The highest Cr contents were found in periprosthetic tissues of patients suffering from aseptic loosening and having more Cr-based implants in the body. Cr species penetrated tissue layers, but their levels decreased with the distance from an implant. The detailed speciation/fractionation study carried out using the set of consecutive periprosthetic tissues of a patient with extensive metallosis showed the presence of trace amounts of free Cr(III), nanoparticles, and metal-protein complexes, but the majority of Cr still occurred in CrPO4 form. Carcinogenic Cr(VI) species were not detected. Up to date, there is no published human tissue study focused on the detailed speciation of both soluble and insoluble Cr-based species in the context of failing total hip and knee replacements.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10406 - Analytical chemistry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Biomedical Materials Research. Part B

ISSN

1552-4973

e-ISSN

1552-4981

Volume of the periodical

111

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

271-283

UT code for WoS article

000851542100001

EID of the result in the Scopus database

2-s2.0-85136159323