Organic Acid to Nitrile: A Chemoenzymatic Three-Step Route
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F23%3A00568108" target="_blank" >RIV/61388971:_____/23:00568108 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/adsc.202201053" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/adsc.202201053</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/adsc.202201053" target="_blank" >10.1002/adsc.202201053</a>
Alternative languages
Result language
angličtina
Original language name
Organic Acid to Nitrile: A Chemoenzymatic Three-Step Route
Original language description
Various widely applied compounds contain cyano-groups, and this functional group serves as a chemical handle for a whole range of different reactions. We report a cyanide free chemoenzymatic cascade for nitrile synthesis. The reaction pathway starts with a reduction of carboxylic acid to aldehyde by carboxylate reductase enzymes (CARs) applied as living cell biocatalysts. The second chemical step includes in situ oxime formation with hydroxylamine. The final direct step from oxime to nitrile is catalyzed by aldoxime dehydratases (Oxds). With compatible combinations of a CAR and an Oxd, applied in one-pot two-step reactions, several aliphatic and aryl-aliphatic target nitriles were obtained in more than 80% conversion. Phenylacetonitrile, for example, was prepared in 78% isolated yield. This chemoenzymatic route does not require cyanide salts, toxic metals, or undesired oxidants in contrast to entirely chemical procedures.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GF20-23532L" target="_blank" >GF20-23532L: A new chemoenzymatic route from carboxylic acids to nitriles</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Synthesis & Catalysis
ISSN
1615-4150
e-ISSN
1615-4169
Volume of the periodical
365
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
37-42
UT code for WoS article
000905397400001
EID of the result in the Scopus database
2-s2.0-85144999023