Paradoxical Reactions to Anti-TNFa and Anti-IL-17 Treatment in Psoriasis Patients: Are Skin and/or Gut Microbiota Involved?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F23%3A00571652" target="_blank" >RIV/61388971:_____/23:00571652 - isvavai.cz</a>
Alternative codes found
RIV/00064211:_____/23:W0000026
Result on the web
<a href="https://link.springer.com/article/10.1007/s13555-023-00904-4" target="_blank" >https://link.springer.com/article/10.1007/s13555-023-00904-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13555-023-00904-4" target="_blank" >10.1007/s13555-023-00904-4</a>
Alternative languages
Result language
angličtina
Original language name
Paradoxical Reactions to Anti-TNFa and Anti-IL-17 Treatment in Psoriasis Patients: Are Skin and/or Gut Microbiota Involved?
Original language description
Psoriasis is a chronic, immune-mediated, inflammatory disease primarily affecting the skin. It is currently coming to light that patients with psoriasis have disrupted intestinal barrier and often suffer from comorbidities associated with the gastrointestinal tract. Moreover, there is growing evidence of both cutaneous and intestinal paradoxical reactions during biologic treatment in patients with psoriasis. This review focuses on barrier defects and changes in immune responses in patients with psoriasis, which play an important role in the development of the disease but are also influenced by modern biological treatments targeting IL-17 and TNF alpha cytokines. Here, we highlight the relationship between the gut-skin axis, microbiota, psoriasis treatment, and the incidence of paradoxical reactions, such as inflammatory bowel disease in patients with psoriasis. A better understanding of the interconnection of these mechanisms could lead to a more personalized therapy and lower the incidence of treatment side effects, thereby improving the quality of life of the affected patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Dermatology and Therapy
ISSN
2193-8210
e-ISSN
2190-9172
Volume of the periodical
13
Issue of the periodical within the volume
4
Country of publishing house
NZ - NEW ZEALAND
Number of pages
23
Pages from-to
911-933
UT code for WoS article
000952922700001
EID of the result in the Scopus database
2-s2.0-85150022380