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Paradoxical Reactions to Anti-TNFa and Anti-IL-17 Treatment in Psoriasis Patients: Are Skin and/or Gut Microbiota Involved?

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F23%3A00571652" target="_blank" >RIV/61388971:_____/23:00571652 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064211:_____/23:W0000026

  • Result on the web

    <a href="https://link.springer.com/article/10.1007/s13555-023-00904-4" target="_blank" >https://link.springer.com/article/10.1007/s13555-023-00904-4</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s13555-023-00904-4" target="_blank" >10.1007/s13555-023-00904-4</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Paradoxical Reactions to Anti-TNFa and Anti-IL-17 Treatment in Psoriasis Patients: Are Skin and/or Gut Microbiota Involved?

  • Original language description

    Psoriasis is a chronic, immune-mediated, inflammatory disease primarily affecting the skin. It is currently coming to light that patients with psoriasis have disrupted intestinal barrier and often suffer from comorbidities associated with the gastrointestinal tract. Moreover, there is growing evidence of both cutaneous and intestinal paradoxical reactions during biologic treatment in patients with psoriasis. This review focuses on barrier defects and changes in immune responses in patients with psoriasis, which play an important role in the development of the disease but are also influenced by modern biological treatments targeting IL-17 and TNF alpha cytokines. Here, we highlight the relationship between the gut-skin axis, microbiota, psoriasis treatment, and the incidence of paradoxical reactions, such as inflammatory bowel disease in patients with psoriasis. A better understanding of the interconnection of these mechanisms could lead to a more personalized therapy and lower the incidence of treatment side effects, thereby improving the quality of life of the affected patients.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30102 - Immunology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Dermatology and Therapy

  • ISSN

    2193-8210

  • e-ISSN

    2190-9172

  • Volume of the periodical

    13

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    NZ - NEW ZEALAND

  • Number of pages

    23

  • Pages from-to

    911-933

  • UT code for WoS article

    000952922700001

  • EID of the result in the Scopus database

    2-s2.0-85150022380