Untargeted Metabolomics and Antibacterial Properties of Streptomyces Species Sourced From Thai Mangrove
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F25%3A00639118" target="_blank" >RIV/61388971:_____/25:00639118 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1155/sci5/5510017" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1155/sci5/5510017</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/sci5/5510017" target="_blank" >10.1155/sci5/5510017</a>
Alternative languages
Result language
angličtina
Original language name
Untargeted Metabolomics and Antibacterial Properties of Streptomyces Species Sourced From Thai Mangrove
Original language description
Novel antimicrobial agents are urgently needed to combat the global threat of antimicrobial resistance. Actinobacteria are remarkable producers of bioactive compounds, which are crucial for the discovery of novel drugs to combat antimicrobial resistance. In the current study, bioactivity, phylogenetic analysis, and a dereplication approach were employed to quickly analyze the metabolomic profiles of selected strains and aid in selection strain prioritization. The aim of this study was to screen Thai actinobacteria isolated from the mangrove ecosystem for antibacterial activities. Taxonomic identification confirmed the classification of these isolates within the genus Streptomyces. Eleven strains identified as Streptomyces yogyakartensis, S. globisporus, S. albiaxialis, S. misionensis, S. iranensis, S. sanyensis, and S. diastaticus. The crude extracts of the selected actinobacteria strains exhibited antibacterial activities, with minimum inhibitory concentrations ranging from 9.9 to 1250 mu g/mL against methicillin-resistant Staphylococcus aureus, Acinetobacter baumannii, and Klebsiella pneumoniae. Mass-guided molecular networking analysis of the crude extract revealed the metabolomic complexity of the isolates. Structurally unique compounds such as desferrioxamine E, elaiophylin, kanchanamycin C, bisacuberin, dehydroxynordicadamine, desmethylenylnocardamine, chymostatinol A, chymostatin B, desferrioxamine G, ferrioxamine E, and legonoxamine A were detected in the crude extracts. Notably, we report the potential of bioactive compounds isolated from Thai mangrove actinobacteria, demonstrating diverse biological activities. This study demonstrated the use of metabolomics to annotate putative bioactive compounds, prioritize strains, and discover novel bioactive metabolites.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientifica
ISSN
2090-908X
e-ISSN
2090-908X
Volume of the periodical
2025
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
5510017
UT code for WoS article
001494937500001
EID of the result in the Scopus database
2-s2.0-105006746486