Regenerating liver uses ammonia to support de novo pyrimidine synthesis and cell proliferation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F25%3A00641452" target="_blank" >RIV/61388971:_____/25:00641452 - isvavai.cz</a>
Alternative codes found
RIV/86652036:_____/25:00641452 RIV/67985823:_____/25:00641452 RIV/68378050:_____/25:00641452 RIV/00216208:11310/25:10505232 and 3 more
Result on the web
<a href="https://www.nature.com/articles/s41467-025-65451-2" target="_blank" >https://www.nature.com/articles/s41467-025-65451-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-025-65451-2" target="_blank" >10.1038/s41467-025-65451-2</a>
Alternative languages
Result language
angličtina
Original language name
Regenerating liver uses ammonia to support de novo pyrimidine synthesis and cell proliferation
Original language description
Liver is endowed with high regenerative activity, so that the tissue regrows in mouse after partial hepatectomy within days. We reason that this requires de novo pyrimidine synthesis to support rapid progression via the cell cycle. We find that suppression of de novo pyrimidine synthesis prevents proliferation in regenerating liver, suppressing liver regrowth. Tracing studies and spatial metabolomics reveal a metabolic shift such that ammonia, normally detoxified to urea in the periportal region under homeostasis, is redirected for generating aspartate and carbamoyl phosphate periportally, and glutamine pericentrally, and these products are utilized as precursors by the de novo pyrimidine synthesis pathway. Our research uncovers a metabolic reprogramming leading to utilization of a toxic byproduct for anabolic pathways that are essential for liver regeneration.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10609 - Biochemical research methods
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Communications
ISSN
2041-1723
e-ISSN
2041-1723
Volume of the periodical
16
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
16
Pages from-to
9664
UT code for WoS article
001608931300034
EID of the result in the Scopus database
2-s2.0-105020893791