Galectin-3 as a therapeutic target in pulmonary hypertension: Molecular mechanisms, drug development directions, and emerging clinical applications

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F25%3A00642752" target="_blank" >RIV/61388971:_____/25:00642752 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/25:00642752
Result on the web
<a href="https://doi.org/10.1016/j.biopha.2025.118756" target="_blank" >https://doi.org/10.1016/j.biopha.2025.118756</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biopha.2025.118756" target="_blank" >10.1016/j.biopha.2025.118756</a>

Result language
angličtina
Original language name
Galectin-3 as a therapeutic target in pulmonary hypertension: Molecular mechanisms, drug development directions, and emerging clinical applications
Original language description
Pulmonary hypertension (PH) remains a devastating cardiovascular disorder with limited targeted treatment. Galectin-3 has emerged as a promising therapeutic target due to its central role in vascular remodeling and inflammation. Galectin-3 exacerbates intimal hyperplasia by influencing endothelial cells through multiple mechanisms. It also contributes to medial hypertrophy and adventitial thickening by activating vascular smooth muscle cells and adventitial fibroblasts. In PH, right ventricular myocardium can be remodeled through galectin-3-mediated activation of cardiac fibroblasts and impaired cardiomyocyte contractility. Galectin-3 also modulates accompanying inflammatory reactions. This review explores the molecular mechanisms of galectin-3 action in PH and evaluates the potential of galectin-3 inhibition as a therapeutic strategy. Targeting galectin-3 represents a novel avenue in PH management but still faces challenges such as drug specificity and clinical efficacy. Future studies should focus on optimizing the structure and performance of galectin-3 inhibitors for clinical application.
Czech name
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Czech description
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Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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