Accelerated dephosphorylation of adenosine phosphates and related compounds in the presence of nanocrystalline cerium oxide

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F16%3A00463206" target="_blank" >RIV/61388980:_____/16:00463206 - isvavai.cz</a>

Alternative codes found

RIV/44555601:13520/16:43887701 RIV/44555601:13440/16:43887701 RIV/61989592:15310/16:33161340

Result on the web

<a href="http://dx.doi.org/10.1039/c6en00086j" target="_blank" >http://dx.doi.org/10.1039/c6en00086j</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c6en00086j" target="_blank" >10.1039/c6en00086j</a>

Result language

angličtina

Original language name

Accelerated dephosphorylation of adenosine phosphates and related compounds in the presence of nanocrystalline cerium oxide

Original language description

Recently, cerium oxide has been used in many exciting applications in biology and medicine, where its enzyme-mimetic abilities can be exploited. A more in-depth understanding of its interactions with biologically relevant molecules is highly desirable. It is shown in this study that certain forms of cerium oxide, namely, the nanocrystalline cerium oxide (nanoceria) prepared by the thermal decomposition of cerium carbonate, may exhibit a remarkable ability to promote the dephosphorylation reactions of nucleotides and related compounds -adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), inosine monophosphate (IMP), cytidine monophosphate (CMP), guanosine monophosphate (GMP), thiamine pyrophosphate (TPP) and thiamine monophosphate (TMP). The dephosphorylation proceeded under relatively mild (ambient) conditions with a rate constant proportional to the concentration of nanoceria and was almost independent of pH. The phosphoester bonds were cleaved through nucleophilic substitution, utilizing the surface hydroxyl groups as nucleophilic agents, whereas the electrophilicity of the phosphorus atoms was enhanced by the Lewis acid effect of the cerium cations. Moreover, more complex biologically relevant molecules may be subjected to degradation in the presence of cerium oxide, namely, a-nicotinamide adenine dinucleotide (NAD). The key characteristics of cerium oxide (surface area, crystallinity) as well as its surface chemistry and dephosphorylation activity are governed by the calcination temperature -the most effective cerium oxides were prepared by annealing at temperatures below ca. 600 degrees C. Notably, certain commercially available cerium oxides exhibited even higher dephosphorylation activity than the in-house nanoceria.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CA - Inorganic chemistry

OECD FORD branch

—

Project

<a href="/en/project/LM2015073" target="_blank" >LM2015073: Nanomaterials and Nanotechnologies for Environment Protection and Sustainable Future</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Environmental Science-Nano

ISSN

2051-8153

e-ISSN

—

Volume of the periodical

3

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

847-856

UT code for WoS article

000381438900018

EID of the result in the Scopus database

2-s2.0-84981294020