Nanocrystalline cerium oxide prepared from a carbonate precursor and its ability to breakdown biologically relevant organophosphates

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F17%3A00475963" target="_blank" >RIV/61388980:_____/17:00475963 - isvavai.cz</a>

Alternative codes found

RIV/44555601:13440/17:43892867 RIV/44555601:13520/17:43892867 RIV/61989592:15310/17:73584076

Result on the web

<a href="http://dx.doi.org/10.1039/c7en00119c" target="_blank" >http://dx.doi.org/10.1039/c7en00119c</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c7en00119c" target="_blank" >10.1039/c7en00119c</a>

Result language

angličtina

Original language name

Nanocrystalline cerium oxide prepared from a carbonate precursor and its ability to breakdown biologically relevant organophosphates

Original language description

The unusual ability of cerium oxide to cleave phosphoester bonds under relatively mild (ambient) conditions was demonstrated using thiamine pyrophosphate (TPP) and nicotinamide adenine dinucleotide (NAD) as model compounds. This phosphatase-mimetic ability can be exploited in biology or medicine, e.g., for protein design, however, it represents a potential threat to vital systems in living organisms, such as the phosphate backbone of DNA and RNA. The ability of cerium oxide to promote the cleavage of the bridging pyrophosphate group in the NAD molecule was examined for the first time, it was shown that the cleavage products differ markedly from the commonly observed products of enzymatic or non-enzymatic hydrolysis of NAD. This ability is highly specific for cerium oxide, it was not observed to a comparable extent with any of the other tested metal oxides (La2O3, Nd2O3, Pr6O11, TiO2, manganese oxide and several iron oxides). The phosphatase-mimetic ability stems from the unique properties of cerium cations and may be related to measurable and, to some extent, adjustable characteristics, such as crystallinity, surface area, Ce3+/Ce4+ ratio or the content of surface functional groups. The in-house prepared nanocrystalline cerium oxide exhibited a markedly higher phosphatase-mimetic ability than the commercial nanoceria. The interactions of the cerium oxide nanoparticles with TPP and NAD were also examined with the aid of molecular dynamics simulations.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10402 - Inorganic and nuclear chemistry

Project

<a href="/en/project/LM2015073" target="_blank" >LM2015073: Nanomaterials and Nanotechnologies for Environment Protection and Sustainable Future</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Environmental Science-Nano

ISSN

2051-8153

e-ISSN

—

Volume of the periodical

4

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

1283-1293

UT code for WoS article

000403554500005

EID of the result in the Scopus database

2-s2.0-85021665460