The nanoscaled metal-organic framework ICR-2 as a carrier of porphyrins for photodynamic therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F18%3A00497329" target="_blank" >RIV/61388980:_____/18:00497329 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3762/bjnano.9.275" target="_blank" >http://dx.doi.org/10.3762/bjnano.9.275</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3762/bjnano.9.275" target="_blank" >10.3762/bjnano.9.275</a>
Alternative languages
Result language
angličtina
Original language name
The nanoscaled metal-organic framework ICR-2 as a carrier of porphyrins for photodynamic therapy
Original language description
Nanosized porphyrin-containing metal-organic frameworks (MOFs) attract considerable attention as solid-state photosensitizers for biological applications. In this study, we have for the first time synthesised and characterised phosphinate-based MOF nanoparticles, nanoICR-2 (Inorganic Chemistry Rez). We demonstrate that nanoICR-2 can be decorated with anionic 5,10,15,20-tetrakis(4-nR-phosphinatophenyl)porphyrins (R = methyl, isopropyl, phenyl) by utilizing unsaturated metal sites on the nanoparticle surface. The use of these porphyrins allows for superior loading of the nanoparticles when compared with commonly used 5,10,15,20-tetrakis(4-arboxyphenyl)porphyrin. The nanoICR-2/porphyrin composites retain part of the free porphyrins photophysical properties, while the photodynamic efficacy is strongly affected by the R substituent at the porphyrin phosphinate groups. Thus, phosphinatophenylporphyrin with phenyl substituents has the strongest photodynamic efficacy due to the most efficient cellular uptake.n
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
<a href="/en/project/GA16-02098S" target="_blank" >GA16-02098S: Metal-organic frameworks with incorporated polymers for gas separation applications</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Beilstein Journal of Nanotechnology
ISSN
2190-4286
e-ISSN
—
Volume of the periodical
9
Issue of the periodical within the volume
NOV
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
2960-2967
UT code for WoS article
000451826500001
EID of the result in the Scopus database
2-s2.0-85058219824