Phosphinatophenylporphyrins tailored for high photodynamic efficacy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F18%3A00494406" target="_blank" >RIV/61388980:_____/18:00494406 - isvavai.cz</a>
Alternative codes found
RIV/61388955:_____/18:00494406 RIV/00216208:11310/18:10383119 RIV/60461373:22330/18:43916975
Result on the web
<a href="http://dx.doi.org/10.1039/c8ob01984c" target="_blank" >http://dx.doi.org/10.1039/c8ob01984c</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c8ob01984c" target="_blank" >10.1039/c8ob01984c</a>

Result language
angličtina
Original language name
Phosphinatophenylporphyrins tailored for high photodynamic efficacy
Original language description
The development of effective photosensitizers is particularly attractive for photodynamic therapy of cancer. Three novel porphyrin photosensitizers functionalized with phosphinic groups were synthesized and their physicochemical, photophysical, and photobiological properties were collected. Phosphinic acid groups ((RRPOOH)-R-1-P-2) attached to the porphyrin moiety (R-1) contain different R-2 substituents (methyl, isopropyl, phenyl in this study). The presence of phosphinic groups does not influence absorption and photophysical properties of the porphyrin units, including the O-2((1)Delta(g)) productivity. In vitro studies show that these porphyrins accumulate in cancer cells, are inherently nontoxic, however, exhibit high phototoxicity upon irradiation with visible light with their phototoxic efficacy tuned by R-2 substituents on the phosphorus centre. Thus, phosphinatophenylporphyrin with isopropyl substituents has the strongest photodynamic efficacy due to the most efficient cellular uptake. We demonstrate that these porphyrins are attractive candidates for photodynamic applications since their photodynamic efficacy can be easily tuned by the R-2 substituent.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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