Interaction of adenosine, modified using carborane clusters, with ovarian cancer cells: A new anticancer approach against chemoresistance
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F21%3A00544526" target="_blank" >RIV/61388980:_____/21:00544526 - isvavai.cz</a>
Result on the web
<a href="http://hdl.handle.net/11104/0321368" target="_blank" >http://hdl.handle.net/11104/0321368</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/cancers13153855" target="_blank" >10.3390/cancers13153855</a>
Alternative languages
Result language
angličtina
Original language name
Interaction of adenosine, modified using carborane clusters, with ovarian cancer cells: A new anticancer approach against chemoresistance
Original language description
Platinum compounds remain the first-line drugs for the treatment of most lethal gynecological malignancies and ovarian cancers. Acquired platinum resistance remains a major challenge in gynecological oncology. Considering the unique physicochemical properties of the metallacarboranes modifier and the significant role of nucleoside derivatives as anticancer antimetabolites, we designed and synthesized a set of adenosine conjugates with metallacarboranes containing iron, cobalt, or chromium as semi-abiotic compounds that influence the cisplatin sensitivity of ovarian cancer cells. Adherent cultures of ovarian carcinoma cell lines and multicellular spheroids, ranging from sensitive to highly resistant including experimental cell lines “not responding” to platinum drugs were used. Iron-containing metallacarborane conjugates showed the best anticancer activity, especially against resistant cells. Compound modified at the C2′ nucleoside position showed the best activity in resistant cancer cells and highly resistant cancer spheroids exposed to cisplatin, increasing cell cycle arrest, apoptosis or necrosis, and reactive oxygen species production. Moreover, it showed high cellular accumulation and did not induce cross-resistance to cisplatin, carboplatin, doxorubicin, paclitaxel, or gemcitabine in long-term cultures. The reference nido-carborane derivative (no metal ions) and unmodified nucleosides were not as effective. These findings indicate that metallacarborane modification of adenosine may sensitize ovarian cancer cells to cisplatin in combination treatment.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
<a href="/en/project/GA19-04630S" target="_blank" >GA19-04630S: Tuning of electrochemical properties of boron polyhedral by advanced substitutions towards their use in bioconjugates: systematic basic research</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancers (Basel)
ISSN
2072-6694
e-ISSN
2072-6694
Volume of the periodical
13
Issue of the periodical within the volume
15
Country of publishing house
CH - SWITZERLAND
Number of pages
48
Pages from-to
3855
UT code for WoS article
000681934500001
EID of the result in the Scopus database
2-s2.0-85111386485