Synthesis of Composites of DNA and Boron Cluster-Metal Complexes and their Assembly into Functional Nanoparticles with Gene Silencing Activity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F25%3A00617150" target="_blank" >RIV/61388980:_____/25:00617150 - isvavai.cz</a>
Result on the web
<a href="https://aces.onlinelibrary.wiley.com/doi/10.1002/cnma.202400606" target="_blank" >https://aces.onlinelibrary.wiley.com/doi/10.1002/cnma.202400606</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cnma.202400606" target="_blank" >10.1002/cnma.202400606</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis of Composites of DNA and Boron Cluster-Metal Complexes and their Assembly into Functional Nanoparticles with Gene Silencing Activity
Original language description
Herein, we describe a new type of building block for nanoconstruction based on the composite of a boron cluster metal-complex (metallacarborane) and therapeutic nucleic acid and their assembly into functional nanoparticles with EGFR oncogene silencing activity. In this direction, a method for oligofunctionalization of a metallacarborane, 3,3’-cobalt-bis(1,2-dicarbollide)(−1) ion, and an automated method for synthesis of DNA-oligonucleotides attached to the metallacarborane core is developed. The obtained building blocks forms nanoparticles with a “chrysanthemum-like” topology that carry a slowly releasing antisense anti-EGFR oligonucleotide silencing EGFR gene efficiently in vitro in a pancreatic carcinoma cell line PANC-1.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
<a href="/en/project/GA21-14409S" target="_blank" >GA21-14409S: Exopolyhedral substitutions at metallacarborane cages and their stereochemistry</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ChemNanoMat
ISSN
2199-692X
e-ISSN
2199-692X
Volume of the periodical
11
Issue of the periodical within the volume
3
Country of publishing house
DE - GERMANY
Number of pages
13
Pages from-to
e20240060
UT code for WoS article
001412090500001
EID of the result in the Scopus database
2-s2.0-105001065070