Cyclodextrin mediated non-aqueous electrophoresis for chiral separations of anionic boron clusters

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F25%3A00619152" target="_blank" >RIV/61388980:_____/25:00619152 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/25:10498961 RIV/00216208:11310/25:10498961

Result on the web

<a href="https://hdl.handle.net/11104/0365876" target="_blank" >https://hdl.handle.net/11104/0365876</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.talanta.2025.128117" target="_blank" >10.1016/j.talanta.2025.128117</a>

Result language

angličtina

Original language name

Cyclodextrin mediated non-aqueous electrophoresis for chiral separations of anionic boron clusters

Original language description

Anionic boron cluster compounds have recently made their way into many areas including medicinal chemistry and sensors due to favorable physical-chemical properties and their various biological activity. Notwithstanding the inherent chirality of these compounds, the exploration of the properties and activity of individual enantiomers remains uncharted territory. The permanent delocalized negative charge enables the electrophoretic mobility of these compounds. Thus, chiral electrophoresis, characterized by minimal consumption of chemicals and a sample, emerges as a promising candidate for a reliable quality control tool. The primary attempts in aqueous electrolytes showed some difficulties related to the limited solubility of these analytes. This study meticulously investigates the electrophoretic behavior and chiral separation of anionic [7,8-nido-C2B9H11]- and cobalt bis(dicarbollide)(1-) derivatives using a methanolic non-aqueous electrolyte with numerous derivatives of cyclodextrins. Randomly substituted hydroxypropyl-β-, methyl-β-, and hydroxypropyl-γ-cyclodextrins were identified as the most effective chiral selectors. The chiral separations delineated herein surpass previously published results in capillary electrophoresis in terms of resolution, peak shape, and the number of theoretical plates. Furthermore, the application of (2-hydroxy-3-N,N,N-trimethylamino)propylated β-cyclodextrin in non-aqueous environment resulted in the chiral separation of seven recently synthesized amino cobalt bis(dicarbollide)(1-) derivatives, thereby, reinforcing the extensive applicability of the developed methodology for different structural types of anionic cobalt bis(dicarbollides)(1-). These results qualify non-aqueous electrophoresis as a valuable tool for the enantiomeric purity control of anionic boron cluster compounds with respect to their further use in various areas.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10402 - Inorganic and nuclear chemistry

Project

<a href="/en/project/EH22_008%2F0004607" target="_blank" >EH22_008/0004607: New Technologies for Translational Research in Pharmaceutical Sciences /NETPHARM</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Talanta

ISSN

0039-9140

e-ISSN

1873-3573

Volume of the periodical

293

Issue of the periodical within the volume

OCT

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

128117

UT code for WoS article

001473477200001

EID of the result in the Scopus database

2-s2.0-105002369633