Modulating the anti-cancer photodynamic efficiency of molybdenum-iodide nanoclusters via ligand design
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F25%3A00627710" target="_blank" >RIV/61388980:_____/25:00627710 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22330/25:43931918
Result on the web
<a href="https://hdl.handle.net/11104/0366742" target="_blank" >https://hdl.handle.net/11104/0366742</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d5tb00401b" target="_blank" >10.1039/d5tb00401b</a>
Alternative languages
Result language
angličtina
Original language name
Modulating the anti-cancer photodynamic efficiency of molybdenum-iodide nanoclusters via ligand design
Original language description
Ligand-stabilized metallic nanoclusters are emerging as promising agents for photodynamic therapy (PDT). This study explores how precisely tailored ligands can optimize the anti-cancer PDT efficiency of molybdenum-iodide nanoclusters. Utilizing click chemistry, we synthesized a series of triazolate-capped nanoclusters by reacting Na2[Mo6I8(N3)6] with dibenzo[a,e]cyclooctyne (DBCO) derivatives. Dynamic light scattering and luminescence measurements confirmed that the bulky DBCO moieties effectively stabilized the nanoclusters in aqueous media, while the appended side chains dictated their colloidal behavior and photosensitizing capabilities. In vitro experiments with HeLa cancer cells revealed that the side chain's nature critically influences cellular uptake and phototoxicity. Positively charged nanoclusters exhibited enhanced cell membrane interactions and potent phototoxic effects, whereas negatively charged counterparts displayed reduced internalization and diminished PDT efficacy. Notably, the nanoclusters maintained consistent phototoxicity even after prolonged exposure to aqueous media, demonstrating the robust stability conferred by the DBCO ligands. These results higlight the potential for fine-tuning molybdenum-iodide nanocluster properties to optimize PDT applications, achieving a delicate balance between water stability, cellular interaction, and phototoxicity, thereby isolating key parameters that govern PDT efficiency.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Materials Chemistry B
ISSN
2050-750X
e-ISSN
2050-7518
Volume of the periodical
13
Issue of the periodical within the volume
21
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
6256-6264
UT code for WoS article
001484961800001
EID of the result in the Scopus database
2-s2.0-105005281818