Arrhythmogenic effect of extracellular K- depletion is prevented by the transverse-axial tubular system in a ventricular cardiac cell model.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388998%3A_____%2F02%3A51020084" target="_blank" >RIV/61388998:_____/02:51020084 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/02:00007136

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Arrhythmogenic effect of extracellular K- depletion is prevented by the transverse-axial tubular system in a ventricular cardiac cell model.

Original language description

In this work, we explored quantitatively the significance of the transverse-axial tubular system (TAT-system) for ventricular cell arrhythmogenesis under conditions of simulated hypokalaemia (low [K+]e). We used a model of mammalian ventricular myocyte that integrates the quantitative description of electrical activity of surface and tubular membrane and the dynamic changes of intracellular ion concentrations. The results predict that the TAT-system plays a significant protecting role against cellular arrhythmogenesis that arises from the enhancement of potassium concentration gradient between tubular and extracellular spaces at low levels of [K+]e. An energy-dependent K+ extrusion pump maintains tubular [K+] at a level higher than the overall [K+]e. This sustains the activation of K+ conductances responsible for action potential repolarization and resting voltage.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

<a href="/en/project/GP204%2F02%2FD129" target="_blank" >GP204/02/D129: Quantitative analysis of effect of tubular system on electrical activity of cardiac cells</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scripta Medica

ISSN

1211-3395

e-ISSN

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Volume of the periodical

75

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

179-186

UT code for WoS article

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EID of the result in the Scopus database

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