Quantitative modelling of effect of transverse-axial tubular system on electrical activity of cardiac cells under low [K+]e.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388998%3A_____%2F02%3A51020137" target="_blank" >RIV/61388998:_____/02:51020137 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/02:00007142
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Quantitative modelling of effect of transverse-axial tubular system on electrical activity of cardiac cells under low [K+]e.
Original language description
In this work, we explored quantitatively the effect of ion concentration changes in the restricted space of transverse-axial tubular system (TAT-system) on ventricular cell arrhythmogenesis under the conditions of low extracellular potassium concentration ([K+]e). The simulations were performed on a model that integrates the quantitative description of electrical activity of surface and tubular membrane with the quantitative description of dynamic changes of intracellular ion concentrations. The resultspredict that the TAT-system plays a significant protecting role in cellular arrhythmogenesis that arises from the enhancement of potassium concentration gradient between tubular and extracellular spaces at low level of [K+]e.
Czech name
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Czech description
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Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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