Role of TAT-system in cardiac excitability: investigation in a quantitative model of a ventricular cardiac cell
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00007141" target="_blank" >RIV/00216224:14110/02:00007141 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Role of TAT-system in cardiac excitability: investigation in a quantitative model of a ventricular cardiac cell
Original language description
To explore the effect of the cardiac transverse axial tubular system (TAT-system) on excitability of ventricular cells, we developed a quantitative model incorporating the function of the tubules. The model was based on a modified quantitative description proposed by Luo and Rudy (Circ Res, 1994;74:1071-96). The modifications are summarized in our previous publication (Pásek M. et al. Scripta Medica, 2002;75:179-86). The morphological parameters of the TAT-system were based on the study of Soeller and Cannel (Circ Res, 1999;84:266-75). The time constants of ionic diffusion between the TAT-system and external solution was set to 250 ms for Ca2+ ions and 63 ms for K+ and Na+ ions. The properties of the tubular and peripheral membrane were set according to recently published data. The results of simulations were strongly affected by incorporation of the TAT-system under the conditions of low external [K+]. The model including TAT-system began to produce early after-depolarizations at cons
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP204%2F02%2FD129" target="_blank" >GP204/02/D129: Quantitative analysis of effect of tubular system on electrical activity of cardiac cells</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
New Frontiers in Basic Cardiovascular Research
ISBN
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ISSN
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e-ISSN
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Number of pages
1
Pages from-to
47
Publisher name
Institute of Molecular Philosophy and Genetics, Slovak Academy of Science
Place of publication
Smolenice
Event location
Smolenice
Event date
Jan 1, 2002
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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