Impact of T-tubules on electrical activity of cardiac cells evaluated in a quantitative model

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F03%3A00008681" target="_blank" >RIV/00216224:14110/03:00008681 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Impact of T-tubules on electrical activity of cardiac cells evaluated in a quantitative model
Original language description
We report here the first quantitative evaluation of the role of the transverse-axial tubular (TAT) system in the electrical activity of cardiac cells. Our approach uses a biophysically-based representation of the TAT-system incorporated into a model of cardiac ventricular cell (Jafri et al., Biophys. J. 1998, 74:1149-68). The model was modified to agree more closely with recent published data. The differential distribution of ion transfer mechanisms in peripheral and tubular membranes was included (e.g.K+ channels; Christé, J. Mol. Cell. Cardiol. 1999, 31:2207-13). Changes of ion concentrations in the TAT-lumen were computed from the total transmembrane ion fluxes and ion exchanges with the pericellular medium. Long term stability of the model was verified at rest and under regular stimulation, the charge conservation principle being respected. The tubular membrane voltage during an action potential was nearly identical with the peripheral membrane voltage, indicating that propagation
Czech name
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Czech description
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Project
<a href="/en/project/GP204%2F02%2FD129" target="_blank" >GP204/02/D129: Quantitative analysis of effect of tubular system on electrical activity of cardiac cells</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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