Modelling t-tubule function in cardiac ventricular myocytes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F07%3A00033625" target="_blank" >RIV/00216224:14110/07:00033625 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Modelling t-tubule function in cardiac ventricular myocytes
Original language description
Cardiac transverse (t-) tubules form a complex network of membrane invaginations in mammalian ventricular myocytes, also known as the transverse-axial tubular system (TATS). Biophysically realistic computer models have been used to investigate experimental ambiguities and aspects of TATS function not currently amenable to experimental investigation: 1. Fraction of cell membrane within the TATS: Detubulation of rat ventricular myocytes causes a ~32% decrease of membrane capacitance whereas optical measurements suggest ~56% of the cell membrane within the TATS. Analysis of factors that may account for this discrepancy, and calculation of the combinations of t-tubule radius, length and density that produce t-tubular membrane fractions of 32% or 56%, suggest that the true fraction is at the upper end of this range. 2. Electrical coupling between the surface and TATS membranes: It has long been speculated that voltage control within the TATS may be inadequate, allowing voltage escape.
Czech name
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Czech description
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Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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