Use of quantitative model to assess the fractional area of t-tubular membrane in ventricular cardiomyocyte.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388998%3A_____%2F07%3A00087168" target="_blank" >RIV/61388998:_____/07:00087168 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Use of quantitative model to assess the fractional area of t-tubular membrane in ventricular cardiomyocyte.
Original language description
The transverse (t-) tubules of cardiac ventricular myocytes create a complex network of membrane invaginations. Many of the key proteins involved in excitation-contraction coupling appear to be located predominantly at the t-tubule membrane. Despite their importance, the fraction of cell membrane within the t-tubules remains unclear: for example, measurement of cell capacitance following detubulation in rat cardiomyocytes suggests 32%, whereas optical measurements suggest up to 65%. We have therefore investigated the factors that may account for this discrepancy. Calculation of the combinations of t-tubule radius, length and density that produce t-tubular membrane fractions of 32% or 56% suggest that the true fraction is at the upper end of this range.
Czech name
Využití matematického modelu pro odhad frakční plochy tubulární membrány u srdečních komorových buněk.
Czech description
Příspěvek popisuje využití matematického modelu pro odhad frakční plochy tubulární membrány u komorových buněk laboratorního potkana a pro analýzu faktorů podílejících se na rozporu experimentálních dat určujících tento parametr.
Classification
Type
D - Article in proceedings
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Engineering Mechanics 2007 : national conference with international participation : book of extended abstracts
ISBN
978-80-87012-06-2
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
213-214
Publisher name
Institute of Thermomechanics AS CR, v. v. i.
Place of publication
Praha
Event location
Svratka
Event date
May 14, 2007
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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