Quantitative exploration of T-tubular membrane parameters in a model of rat ventricular cardiomyocyte
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00014820" target="_blank" >RIV/00216224:14110/05:00014820 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Quantitative exploration of T-tubular membrane parameters in a model of rat ventricular cardiomyocyte
Original language description
Formamide-induced detubulation of rat ventricular cardiac myocytes causes an ~32% decrease of membrane capacitance (Despa et al, 2003). Detailed microscopic analysis of the transverse-axial tubular system (TATS) by Soeller and Cannel (1999) showed a meantubule diameter of 255 nm, a mean segment length of 6.87 ľm, a tubule density of 0.3 ľm-2, fractional volume of 3.6% and TATS membrane area to cell volume ratio of 0.44 ľm2/ľm3. These parameters can be approximately respected when the fraction of the total sarcolemma within the TATS is 56%. To explore possible causes for this discrepancy we used a quantitative model of the rat ventricular myocyte that included a description of TATS. Two explanations were found that could account quantitatively for thediscrepancy: (i) incomplete detubulation leaving electrical access to a large area of TATS membrane, due to the branched TATS network. The estimate of Despa et al. could be met if 42% of TATS remained accessible after detubulation. (ii) t
Czech name
Kvantitativní vyšetření parametrů tubulární membrány prostednictvím modelu komorové buňky potkana
Czech description
Cílem práce bylo objasnit rozdíly v publikovaných parametrech transverzálně-axiálního tubulárního systému potkana prostřednictvím matematického modelu.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Molecular and Cellular Cardiology
ISSN
0022-2828
e-ISSN
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Volume of the periodical
39
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
2
Pages from-to
177-178
UT code for WoS article
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EID of the result in the Scopus database
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