Acute effects of ethanol on action potential and intracellular Ca2+ transient in cardiac ventricular cells: a simulation study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388998%3A_____%2F16%3A00453143" target="_blank" >RIV/61388998:_____/16:00453143 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/16:00088865
Result on the web
<a href="http://dx.doi.org/10.1007/s11517-015-1366-8" target="_blank" >http://dx.doi.org/10.1007/s11517-015-1366-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11517-015-1366-8" target="_blank" >10.1007/s11517-015-1366-8</a>

Result language
angličtina
Original language name
Acute effects of ethanol on action potential and intracellular Ca2+ transient in cardiac ventricular cells: a simulation study
Original language description
Alcohol consumption may result in electrocardiographic changes and arrhythmias, at least partly due to effects of ethanol on cardiac ionic currents. Contractility and intracellular Ca2+ dynamics seem to be altered as well. In this study, we integrated the available (mostly animal) experimental data into previously published models of the rat and human ventricular myocytes to assess the share of ionic current components in ethanol-induced changes in AP configuration and cytosolic Ca2+ transient in ventricular cardiomyocytes. The rat model reproduced well the experimentally observed changes in AP duration (APD) under ethanol (slight prolongation at 0.8 mM and shortening at 8 mM). These changes were almost exclusively caused by the ethanol-induced alterations of IK1. The cytosolic Ca2+ transient decreased gradually with the increasing ethanol concentration as a result of the ethanol-induced inhibition of ICa. In the human model, ethanol produced a dose-dependent APD lengthening, dominated by ethanol effect on IKr, the key repolarising current in human ventricles. This effect might contribute to the clinically observed proarrhythmic effects of ethanol in predisposed individuals.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
—

Project
<a href="/en/project/NT14301" target="_blank" >NT14301: Effect of ethanol and its principle metabolite acetaldehyde on cardiac inward rectifier potassium currents: a link to atrial fibrillation related to alcohol consumption?</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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