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Modification of DNA radiolysis by DNA-binding proteins: Structural aspects

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F07%3A00075976" target="_blank" >RIV/61389005:_____/07:00075976 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Modification of DNA radiolysis by DNA-binding proteins: Structural aspects

  • Original language description

    The radiolysis of DNA-protein complexes is studied for: 1) the E. coli lactose operator-repressor complex, 2) the complex between DNA bearing an analogue of an abasic site and the repair protein Fpg of Lactococcus Lactis. Experimental patterns of DNA damages are presented and compared to predicted damage distribution obtained using an improved version of the stochastic model RADACK. The same method is used for predicting the location of damages on the proteins.

  • Czech name

    Vliv proteinů interagujících s DNA na radiolýzu DNA. Strukturní aspekty

  • Czech description

    Radiolýza DNA-proteinových komplexů je studována pro: 1) komplex E. coli lac operatoru s lac represorem, 2) komplex mezi DNA nesoucí analog abasického místa a reparačním proteinem Fpg Lactococcus Lactis. Experimentální distribuce poškození DNA jsou prezentovány a porovnány s predikcemi distribucí poškození získanými aktualizovanou verzí stochastického modelu Radack. Stejná metoda je použita pro predikci poškození v proteinech.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/1P05OC085" target="_blank" >1P05OC085: Radiation damage to DNA protein complexes</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Radiation Protection Dosimetry

  • ISSN

    0144-8420

  • e-ISSN

  • Volume of the periodical

    122

  • Issue of the periodical within the volume

    1-4

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    6

  • Pages from-to

    100-105

  • UT code for WoS article

  • EID of the result in the Scopus database