RADAMOL tool: Role of radiation quality and charge transfer in damage distribution along DNA oligomer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F14%3A00435969" target="_blank" >RIV/61389005:_____/14:00435969 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1140/epjd/e2014-50068-8" target="_blank" >http://dx.doi.org/10.1140/epjd/e2014-50068-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1140/epjd/e2014-50068-8" target="_blank" >10.1140/epjd/e2014-50068-8</a>

Result language

angličtina

Original language name

RADAMOL tool: Role of radiation quality and charge transfer in damage distribution along DNA oligomer

Original language description

Theoretical modeling is a powerful tool to predict radiation damage of biomolecules such as DNA, proteins and more complex biological targets. In this paper, we present damage distributions along a DNA oligomer irradiated by 10 keV electrons, 1, 2, 5, 10and 20 MeV protons and alpha particles predicted by the simulation tool RADAMOL. The scavengeable damage of base and deoxyribose moieties due to radical attack is more important in the studied system than unscavengeable ionizations of the DNA target andsurrounding bound water layer. Radiation quality does not modify distribution of primary damages along the DNA, but changes overall damage yields. For the first time, electron and hole migration along the DNA macromolecule has been taken into account inthe simulation procedure. The effect of these processes on distribution of DNA damages is demonstrated.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

<a href="/en/project/LD12008" target="_blank" >LD12008: Effect of high LET radiation on specific interaction of proteins with DNA.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Physical Journal D

ISSN

1434-6060

e-ISSN

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Volume of the periodical

68

Issue of the periodical within the volume

8

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

240-247

UT code for WoS article

000346058600009

EID of the result in the Scopus database

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